مقالة علمية
Gene Pair Correlation Coecients in Sphingolipid Metabolic Pathway as a Potential Prognostic Biomarker for Breast Cancer

Sakharkar, Meena Kishore.


مرفقات :
(1)

 

Gene Pair Correlation Coecients in Sphingolipid Metabolic Pathway as a Potential Prognostic Biomarker for Breast Cancer

Sakharkar, Meena Kishore.

Complex diseases such as cancer are usually governed by dynamic and simultaneous modifications of multiple genes. Since sphingolipids are potent bioactive molecules and regulate many important pathophysiological processes such as carcinogenesis, we studied the gene pair correlations of 36 genes (31 genes in the sphingolipid metabolic pathway and 5 genes encoding the sphingosine-1-phosphate receptors) between breast cancer patients and healthy controls. It is remarkable to observe that the gene expressions were widely and strongly correlated in healthy controls but in general lost in breast cancer patients. This study suggests that gene pair correlation coecients could be applied as a systematic and novel method for the diagnosis and prognosis of breast cancer.

Complex diseases such as cancer are usually governed by dynamic and simultaneous modifications of multiple genes. Since sphingolipids are potent bioactive molecules and regulate many important pathophysiological processes such as carcinogenesis, we studied the gene pair correlations of 36 genes (...

مادة فرعية

المؤلف : Sakharkar, Meena Kishore.

مؤلف مشارك : Dhillon, Sarinder Kaur

بيانات النشر : Cancer، 2020مـ.

التصنيف الموضوعي : العلوم التطبيقية|العلوم الطبية .

المواضيع : sphingolipid .

gene expression .

gene pair correlation .

المصدر : MDPI : Switzerland.

لا توجد تقييمات للمادة