Primary hyperaldosteronism (PA) is a common disease with a prevalence of 5-10% in unselected patients with hypertension. Medullary nephrocalcinosis is a radiological diagnosis and refers to diffuse calcification in the renal parenchyma. The three commonest causes of nephrocalcinosis are PHPT, distal renal tubular acidosis and medullary sponge kidney. PA is not a recognized cause of nephrocalcinosis. In the literature there are few case reports linking PA with nephrocalcinosis. In this case series, we report three cases where PA was possibly associated with medullary nephrocalcinosis. In all three cases, the common causes of nephrocalcinosis were excluded by careful clinical history, biochemical evalution and radiologic findings. We conclude and emphasize that PA as an etiology of medullary nephrocalcinosis should be sought after the common causes have been excluded, at least in those with hypertension that is difficult to control.

Primary hyperaldosteronism (PA) is a common disease with a prevalence of 5-10% in unselected patients with hypertension. Medullary nephrocalcinosis is a radiological diagnosis and refers to diffuse calcification in the renal parenchyma. The three commonest causes of nephrocalcinosis are PHPT, distal...