Objectives: Stem cell therapy is a promising approach in the treatment of acute myocardial infarction (AM I). Mesenchymal stem cells (MSC) from bone marrow (BM -MSC) and adipose tissue (AT-MSC) are attractive and feasible for preclinical and clinical trials. In this study, we compared the therapeutic potential of BM -MSC and AT-MSC in repairing the hearts of rats with isoproterenol (ISO)-induced AM I. Methods: Forty-two female rats were assigned into two groups; the optimization and the experimental group. The optimization groups were further subdivided into control group and the AM I induced group (using ISO). The experimental group was subdivided into AM I+cell-free media injected in the tail vein, AM I+BM -MSC, and AM I+AT-MSC groups treated with the intravenous injection of their respective cell types. Twenty-eight days after induction, electrocardiogram (ECG) was performed, and heart tissue samples were collected for histological assessment and cells tracing. Results: MSC therapy repaired cardiac functions shown by the restoration of ST segment, QT and QRS intervals in the ECG when compared to the AM I group. Infarct area was significantly decreased, and cardiac tissue regeneration signs were shown on histopathological examination. Conclusions: Both MSC sources proved to be equally efficient in the assessed parameters.

Objectives: Stem cell therapy is a promising approach in the treatment of acute myocardial infarction (AM I). Mesenchymal stem cells (MSC) from bone marrow (BM -MSC) and adipose tissue (AT-MSC) are attractive and feasible for preclinical and clinical trials. In this study, we compared the therape...