Objectives: Low cardiac output resulting in reduction in tissue oxygen delivery and hypoperfusion could occur at any time during cardiopulmonary bypass (CPB). This could result in tissue hypoxia that could lead to serum lactate generation as well as adverse effects on the kidneys. Hence, if an intraoperative parameter like serum lactate level could predict postoperative renal dysfunction, recourse to advanced renal function markers could be avoided and corrective measures could be taken to prevent overt post CPB related renal failure. The primary aim of this study was to seek a correlation between the highest serum lactate levels measured throughout surgery and postoperative creatinine (Cr) clearance levels that was empirically considered as a surrogate marker for early identification of renal dysfunction. Also, we aimed to identify any correlation between highest intraoperative serum lactate levels with inotrope score, duration of CPB, intraoperative hematocrit, duration of ventilation, and intensive care unit (ICU) and hospital stay. Methods: A cohort prospective observational study of patients scheduled for elective coronary artery bypass grafting surgery over a period of two months in a single tertiary cardiac care center. One hundred consenting patients were enrolled. The baseline demographic data, laboratory investigations, EURO score II, operative data, cross clamping, and total bypass time were recorded. Intraoperatively, the serum lactate levels were measured from time of arterial line insertion, and almost every 30−45 minutes throughout the surgery until patients were transferred to cardiac ICU. The inotrope score at the time of shifting to ICU was also recorded. Postoperatively, the serum Cr for the first 48 hours, total intubation time, and ICU and hospital stay were also documented in each patient. The data were transferred to EPI-DATA and was

Objectives: Low cardiac output resulting in reduction in tissue oxygen delivery and hypoperfusion could occur at any time during cardiopulmonary bypass (CPB). This could result in tissue hypoxia that could lead to serum lactate generation as well as adverse effects on the kidneys. Hence, if an ...