ورقة بحثية
العدوى الانتهازية والمضاعفات عند الإصابة بفيروس نقص المناعة البشرية- 1 في الأطفال والارتباط مع الحالة المناعية = Opportunistic Infections and Complications in Human Immunodeficiency Virus-1-Infected Children Correlation with immune status

Yadav, Jaivinder.


 

العدوى الانتهازية والمضاعفات عند الإصابة بفيروس نقص المناعة البشرية- 1 في الأطفال والارتباط مع الحالة المناعية = Opportunistic Infections and Complications in Human Immunodeficiency Virus-1-Infected Children Correlation with immune status

Yadav, Jaivinder.

Objectives: The aim of this study was to ascertain the correlation between various opportunistic infections and complications in human immunodeficiency virus (HIV)-1-infected children and the immune status of these patients, evaluated by absolute cluster of differentiation 4 (CD4) count and CD4 percentage. Methods: This study was conducted from January 2009 to June 2010 at the Antiretroviral Treatment Centre of the Pt. B.D. Sharma Post Graduate Institute of Medical Sciences, a tertiary care hospital in Rohtak, Haryana, in northern India. A total of 20 HIV-1-infected children aged 4–57 months were studied. Demographic and baseline investigations were performed prior to the start of highly active antiretroviral therapy (HAART). A fixed-dose combination of HAART was given based on the patient’s weight. Baseline investigations were repeated after six months of HAART. Results: There was a significant increase in the patients’ haemoglobin, weight, height and CD4 count after six months of HAART. Significant improvements (P <0.05) were also noted in the patients’ immune status, graded according to the World Health Organization. Conclusion: This study observed that the severity and frequency of opportunistic complications in paediatric patients with HIV-1 increased with a fall in the CD4 count. The treatment of opportunistic infections, along with antiretroviral therapy, may lead to both clinical and immunological recovery as well as a decreased incidence of future opportunistic infections. The CD4 count may give treating physicians an initial idea about the immune status of each child and could also be used as a biological marker of HAART efficacy. Patient compliance must be ensured during HAART as this is a key factor in improving outcomes.

Objectives: The aim of this study was to ascertain the correlation between various opportunistic infections and complications in human immunodeficiency virus (HIV)-1-infected children and the immune status of these patients, evaluated by absolute cluster of differentiation 4 (CD4) count and CD4 pe...

مادة فرعية

المؤلف : Yadav, Jaivinder.

مؤلف مشارك : Sanjeev Nanda
Deepak Sharma

بيانات النشر : Muscat، Sultanate of Oman : Sultan Qaboos University / College of Medicine and Health Sciences، 2014مـ.

التصنيف الموضوعي : العلوم التطبيقية|العلوم الطبية .

المواضيع : Human Immunodeficiency Virus in children .

فيروس نقص المناعة البشرية لدى الأطفال .

رقم الطبعة : 4

المصدر : Sultan Qaboos University / College of Medicine and Health Sciences : Muscat، Sulatante of Oman.

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