ورقة بحثية
العلاقة بين مَنْسِب تقييم نموذج الاستباب ومستويات الأديبونيكتن واللبتين والأنسولين ومنسب كتلة الجسم المرتبط بتعدد الأشكال الجينية عند المراهقين = Correlation of the Homeostasis Model Assessment Index and Adiponectin, Leptin and Insulin Levels to Body Mass Index-Associated Gene Polymorphisms in Adolescents

Martínez Martínez, María D.


 

العلاقة بين مَنْسِب تقييم نموذج الاستباب ومستويات الأديبونيكتن واللبتين والأنسولين ومنسب كتلة الجسم المرتبط بتعدد الأشكال الجينية عند المراهقين = Correlation of the Homeostasis Model Assessment Index and Adiponectin, Leptin and Insulin Levels to Body Mass Index-Associated Gene Polymorphisms in Adolescents

Martínez Martínez, María D.

Objectives: This study aimed to describe correlations between glucose, insulin and adipokine levels and the homeostasis model assessment (HOMA) index with regards to the presence/absence of fat mass and obesityassociated (FTO) rs9939609 and peroxisome proliferator-activated receptor (PPAR)-y rs1801282 single nucleotide polymorphisms (SNPs) as indicators of body mass index in adolescents. Methods: This cross-sectional study was conducted between September and December 2016 in Toluca, Mexico. A total of 71 students between 14–18 years old were included. Various anthropometric and laboratory measurements were collected, including lipid profile, glucose, insulin and adipokine levels and HOMA index. The degree of association between variables was evaluated with regards to the presence/absence of the SNPs. Results: Leptin levels were significantly higher among female students (P = 0.001), although adiponectin levels did not differ significantly (P = 0.060). There were significant positive correlations between insulin levels and HOMA index with FTO (r = 0.391; P = 0.007 and r = 0.413; P = 0.005, respectively) and PPARγ (r = 0.529; P = 0.007 and r = 0.537; P = 0.007, respectively) SNPs. Leptin showed a significant positive correlation in the presence of PPARγ (r = 0.483; P = 0.007) or in the absence of both SNPs (r = 0.627; P = 0.039). However, adiponectin was significantly negatively correlated in the presence of FTO, either alone (r = −0.333; P = 0.024) or in combination with PPARγ (r = −0.616; P = 0.043). Conclusion: The presence of FTO and/or PPARγ SNPs might be related to a genetic predisposition to metabolic syndrome.

Objectives: This study aimed to describe correlations between glucose, insulin and adipokine levels and the homeostasis model assessment (HOMA) index with regards to the presence/absence of fat mass and obesityassociated (FTO) rs9939609 and peroxisome proliferator-activated receptor (PPAR)-y rs180...

مادة فرعية

المؤلف : Martínez Martínez, María D.

مؤلف مشارك : Mendieta Zerón, Hugo
Luis Celis
Layton Tovar, Cristian F
Torres García, Rocío
Gutierrez Pliego, Laura E
Camarillo Romero, Eneida
Garduno Garcia, Jose D
Camarillo Romero, María D

بيانات النشر : Muscat، Sultanate of Oman : Sultan Qaboos University / College of Medicine and Health Sciences، 2018مـ.

التصنيف الموضوعي : العلوم التطبيقية|العلوم الطبية .

المواضيع : Obesity .

البدانة .

Body Mass Index .

مؤشر كتلة الجسم .

رقم الطبعة : 3

المصدر : Sultan Qaboos University / College of Medicine and Health Sciences : Muscat، Sulatante of Oman.

لا توجد تقييمات للمادة