ورقة بحثية
Synthesis of a Flavone Based Fluorescent Probe Bearing a Nitroolefin Moiety for Selective Detection of Cysteine = التحضير الكيميائي لكاشف ضوئي فالفوني يحتوي على مجموعة نيتروأولوفين للكشف الإنتقائي للحمض الأميني سيستين

Al Busafi, Saleh N.


 

Synthesis of a Flavone Based Fluorescent Probe Bearing a Nitroolefin Moiety for Selective Detection of Cysteine = التحضير الكيميائي لكاشف ضوئي فالفوني يحتوي على مجموعة نيتروأولوفين للكشف الإنتقائي للحمض الأميني سيستين

Al Busafi, Saleh N.

In this paper, we report the synthesis, characterization and investigation of the optical properties of a new fluorescent probe, 4ʹ-nitroolefinylflavone (4ʹ-NOF) 1, based on a flavone skeleton and bearing a nitroolefin moiety. Upon the addition of cysteine, a remarkable fluorescence enhancement (200 fold) was observed for probe 1 accompanied with a slight blue shift from 457 nm to 459 nm. The prepared probe displays high selectivity and sensitivity towards cysteine over other amino acids. The Michael addition of cysteine to probe 1 was confirmed by 1HNMR spectroscopy. The detection limit of probe 1 towards cysteine was found to be 1.63 μΜ, a lower concentration than the normal human cysteine level, 30-200 μΜ

In this paper, we report the synthesis, characterization and investigation of the optical properties of a new fluorescent probe, 4ʹ-nitroolefinylflavone (4ʹ-NOF) 1, based on a flavone skeleton and bearing a nitroolefin moiety. Upon the addition of cysteine, a remarkable fluorescence enhancement (200...

مادة فرعية

المؤلف : Al Busafi, Saleh N.

مؤلف مشارك : Al Hamami, Nadia M
Suliman, Fakhr Eldin O
Varghese, Beena

بيانات النشر : Muscat، Sultanate of Oman : Sultan Qaboos Journal of Science، 2018مـ.

التصنيف الموضوعي : العلوم البحتة| .

المواضيع : Chemistry .

الكيمياء .

رقم الطبعة : 2

المصدر : Sultan Qaboos University : Muscat، Sultanate of Oman.

لا توجد تقييمات للمادة